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10 ADHD Medication Mistakes Even Doctors Make. There is no such thing as an “average dose of Adderall” or an optimal prescription for all adults with ADD or a side effect that should be ignored. Sadly, many doctors don’t know these ADHD medication rules. So study up — and speak up! — to minimize symptoms and optimize your treatment plan. Jump to Lethal dosage - Your doctor may gradually increase your dose until your symptoms are controlled. What's the lethal dosage? The amount that could.
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Attention Deficit Hyperactivity DisorderNot recommended for children under 3 years of age. In children from 3 to 5 years of age, start with 2.5 mg daily; daily dosage may be raised in increments of 2.5 mg at weekly intervals until optimal response is obtained.In children 6 years of age and older, start with 5 mg once or twice daily; daily dosage may be raised in increments of 5 mg at weekly intervals until optimal response is obtained. Only in rare cases will it be necessary to exceed a total of 40 mg per day. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours.Where possible, drug administration should be interrupted occasionally to determine if there is a recurrence of behavioral symptoms sufficient to require continued therapy. NarcolepsyUsual dose 5 mg to 60 mg per day in divided doses, depending on the individual patient response.Narcolepsy seldom occurs in children under 12 years of age; however, when it does, dextroamphetamine sulfate may be used. The suggested initial dose for patients aged 6 to 12 is 5 mg daily; daily dose may be raised in increments of 5 mg at weekly intervals until optimal response is obtained.
In patients 12 years of age and older, start with 10 mg daily; daily dosage may be raised in increments of 10 mg at weekly intervals until optimal response is obtained. If bothersome adverse reactions appear (e.g., insomnia or anorexia), dosage should be reduced. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours. Further informationAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Related questions.
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Let's presume that you've been prescribed 20mg Adderall, but want to switch to Vyvanse. What's an equivalent dose of Vyvanse that would be comparable to 20mg of Adderall?It turns out that comparing Vyvnase vs Adderall dosages is not straightforward, for a number of reasons. But we've made a handy chart to make converting between Adderall and Vyvanse dosages a little easier.adjusted for relative potency of d-amphetamine: l-amphetamine How to Read This ChartLet's say you normally take 10mg of Adderall, twice a day. What would be the equivalent dose of Vyvanse?You'll notice that a 20 mg total dose of Adderall corresponds to 37 mg of Vyvanse. Now, there isn't a Vyvanse capsule that contains exactly 37 mg, but your psychiatrist can be prescribe you 30 mg or 40 mg (which are available), at their discretion.To convert from an Adderall dosage to the equivalent dose of Vyvanse, multiple your Adderall dose by 1.85The calculation to arrive at these dose equivalences is actually fairly convoluted.
The molecular weights of lisdexamfetamine dimesylate (Vyvanse) and the four amphetamine salts that comprise Adderall, as well as all the relevant counter-ions were taken into account.The above table reveals that a 30 mg dose of lisdexamfetamine dimesylate (Vyvanse) contains roughly 8.9mg of d-amphetamine (based on the relative molecular weights of the components).However, Adderall contains both a mixture of d-amphetamine (3/4) and l-amphetamine (1/4). L-amphetamine, it turns out, is about 1/2 as potent as d-amphetamine. Therefore a 30mg dose of Adderall containing 14.2mg of d-amp and 4.5mg of l-amp will be roughly equivalent to a 16.45mg dose of d-amp. D-Amphetamine vs L-Amphetamine PotencyI suggested previously that the potency of d-amphetamine to l-amphetamine is 2:1, i.e., d-amp is twice as potent.
What is this claim based on?A conducted in 16 healthy volunteers in 1997 reported an efficacy ratio of 2:1. However, other studies have questioned the validity of these results and so the precise difference in potency remains disputed.The pharmacology underlying this difference in potency is complex, but is probably in part related to the observation that d-amphetamine inhibits noradrenaline (NE) reuptake almost twice as strongly, and dopamine reuptake almost five times as strongly compared with l-amphetamine. However, this is only part of the story since amphetamine is also a potent monoamine releasing agent.
Amphetamine's activity as a releasing-agent is more important to its therapeutic action than as a re-uptake inhibitor.#Vyvanse vs Adderall: Pros & Cons Vyvanse Pros & ConsAdderall Pros & ConsSlow release mechanism allows for longer relief from ADHD symptomsMay be more effective for some times of ADHDMore expensive, generics are unavailableLess expensive, generics availableLess abuse potentialGreater risk of psychological dependenceSlow release has better tolerabilityBetter control of dosing (e.g., can take only one Adderall if only 6 hours of symptom relief is needed).
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